Sam Battle aka Appear Mum No Laptop, a DIY musician and creator of the Furby Organ, has just released a video displaying off his Sega Master Method Synthesizer. In the video he requires a Sega Master Method II, creates a rack-sized breakout board, and utilizes a SEGA Master Method MIDI Interface device developed by Small Scale to handle the sound.
As noted by Sam in the video, the console has a SN76489A PSG (programmable sound generator) chip and does not have the Yamaha YM2312 FM chip inside. (Japanese Master Systems and the Sega Mark III contained this chip).
The SN76489A sound chip has 4 channels: 3 square wave tone generators and a single noise generator. When the chip inside these systems are clones of the original Texas Instruments version and constructed into the VDP (video show processor), they are just about functionally identical to the ones discovered in the Colecovision and IBM PCjr.
Sam has other video game method-associated videos up which includes a gigantic Game Boy Mega Machine constructed out of 48 Game Boys, and he teased a achievable 100-button Sega Mega Drive (Genesis) synthesizer in the future.
Skip to eight:42, for a demonstration of the sort of music the Sega Master Method II is capable of.